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The study employed a stepwise approach beginning with pharmacokinetic evaluation before moving into a longer open-label treatment phase, with comprehensive safety and efficacy assessments [2]

This once-weekly injection is ideal for individuals who have completed the dose-escalation process (0.25 mg, 0.5 mg, 1.0 mg, and 1.7 mg)

Patients who remained depressed several months after the initial assessment had lower salivary DHEA-to-cortisol ratios at baseline [109

By controlling for BMI, diabetes, and other health factors, the study strengthens the link between GLP-1 exposure and enhanced sperm count, suggesting a potential therapeutic role for GLP-1s in male infertility management
