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They help reduce appetite

However, despite their significant quality of life improvements, they can be accompanied by significant gastrointestinal side effects, including nausea, vomiting, abdominal pain, diarrhea, fatigue, and weight loss 16

An increased intestinal absorption of bile acids stimulates the secretion of FGF19 from intestinal enterocytes (26), and increasing circulating levels of both bile acids and FGF19 inhibit hepatic bile acid synthesis, as mentioned above

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PMID: 28831150 Guo XH (2016): The value of short- and long-acting glucagon-like peptide-1 agonists in the management of type 2 diabetes mellitus: experience with exenatide