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Mendelian randomisation for mediation analysis: current methods and challenges for implementation

it is only accessible through approved clinical trials, with phase 3 results still awaited as of 2025

Future research must focus on developing precision medicine strategies, expanding indications through rigorous trials, and creating accessible and affordable solutions to combat the ever-increasing global burden of CVD and related metabolic disorders

226 Aberrant sialylation can promote CD4 + T-cell activation, leading to the occurrence of UC, while deficiency of the -2,6-sialyltransferase ST6GAL1 inhibits the process of sialylation and limits CD4 + T cell activation by suppressing the expression of NF-B, subsequently decreasing the production of proinflammatory cytokines and alleviating UC

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