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They also suggest anti-obesity pharmacotherapy for patients with a BMI over 27 who have no contraindications and have not succeeded in losing weight through lifestyle changes alone [68]

This personalization accounts for the relationship between body mass and peptide distribution

Neural circuits driven by GLP-1 and GLP-1R in the NTS and hypothalamus has been shown to contribute to many aspects of energy balance control 4,6

There is growing interest in drug therapies that can support weight loss and thereby reduce the prevalence of obesity and obesity-related complications

However, prescribing authority differs from prescribing readiness