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219 It has been postulated that the ability of GLP-1 to enhance metabolism may decrease endoplasmic reticulum stress via increasing mitochondrial production of ATP and Ca 2+ , which could be utilised for assisting endoplasmic reticulum homeostasis

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This action on both energy intake and expenditure has been observed in clinical studies, where participants reported less hunger and better appetite control (Jastreboff et al

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