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While numerous preclinical and clinical studies have demonstrated that GLP-1 can access various nuclei associated with energy homeostasis and hedonic eating in the CNS via bloodbrain barrier (BBB), research on the activity of SGLT-2is remains limited

Add to that an environment filled with ultraprocessed foods, oversized portions, high stress and limited time for movement, and it's no surprise that so many people's weight ends up yo-yoing despite their best efforts

Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon receptor agonism, making it a triple agonist with distinct pharmacological properties under study

Effect of the sodium-glucose cotransporter 2 inhibitor canagliflozin for heart failure with preserved ejection fraction in patients with type 2 diabetes