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The relevance of these mechanisms extends to neuropsychiatric domains

ten Kulve JS, Veltman DJ, Gerdes VEA, van Bloemendaal L, Barkhof F, Deacon CF, et al

J Biol Chem 1992

In fact, indirect inhibition of GLP-1 secretion via sc injection of octreotide, a somatostatin analog, enhances computer mouse clicks for chocolate rewards in individuals who underwent RYGB surgery but not in obese non-operated controls, suggesting that RYGB surgery influences the effects of GLP-1 signaling on food-motivated responses [99]

For blood glucose control , many patients notice improvements within the first few days to two weeks of treatment, as the medication begins to enhance insulin secretion and suppress glucagon release