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Adult people (18 years) with a diagnosis of obesity (body mass index30 kg/m2) or T2DM (ICD-10-CM: E11) between 2018 and 2024 were subdivided in two mutually exclusive cohorts: (1) GLP-1 RA Users

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The 0.25mg starting dose of semaglutide is a standard initiation strategy designed to minimize side effects, but whether it is sufficient depends on individual biomarkers, genetic predispositions, and clinical response over time