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Very elderly, frail adults with limited life expectancy and high sarcopenia risk may suffer more harm than benefit from aggressive weight loss

60 When gallstones obstruct the cystic duct, bile flow is impeded, resulting in bile stasis and increased pressure within the gallbladder

GLP-1s are incretin-based agents that amplify glucose-stimulated insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety

GLP-1 medications are powerful tools for weight loss but reduced appetite means reduced nutrient intake, and that creates real risks: muscle loss, micronutrient deficiency, hair thinning, and digestive disruption