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No one owes me an explanation for how and why they decided to pursue weight loss, and I dont think its always problematic
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In three different species (i.e., mice, rats, and musk shrews), we show that glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling blocks emesis and attenuates illness behaviors elicited by GLP-1R activation, while maintaining reduced food intake, body weight loss, and improved glucose tolerance
Retatrutide Phase 2 showed 24.2% at 12mg over just 48 weeks more weight in less time
