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Like GLP-1s, they have been touted by wealthy, high-profile figures, including Gwyneth Paltrow, Joe Rogan, and Health Secretary Robert F

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Receptors of these incretins, GLP-1R and GIPR are G protein-coupled receptors (GPCR) that activate the classical signaling cascade through Gs and adenylate cyclase (Adcy), leading to increased cAMP production [6,7]

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