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The number of clusters (k=5) was chosen objectively by maximizing a combined score of: Silhouette coefficient on a discovery split: measures how well-separated the clusters are internally Adjusted Rand Index (ARI) on a held-out validation split: measures whether an independent reclustering of new data produces the same structure This two-stage validation approach guards against over-fitting the cluster count to a single sample

Importantly, stopping GLP-1s does not mean failure

En los prximos aos post-comercializacin debe evaluarse la incidencia de estos efectos adversos para definir su relacin causal o no

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a breakthrough therapy for obesity, overweight, and other associated health conditions, delivering unprecedented weight loss in clinical trials

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