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These areas correspond to regional distribution differences between semaglutide and liraglutide, which may explain the discrepancies between the 2 GLP-1RAs by virtue of differences in GLP-1R interaction in these specific brain regions

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For persistent bile acid diarrhoea, your GP may refer you to a gastroenterologist for assessment (potentially including SeHCAT testing) and consider bile acid sequestrants such as colestyramine

In the echocardiography substudy, researchers found that once weekly semaglutide (2.4 mg) improved multiple domains of cardiac structure and cardiac function, including improved left atrial volume, left ventricular diastolic function and right ventricular size, compared with placebo