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endogenous glp 1 Physiological vs pharmacological actions of GLP-1. Nutrients stimulate Glucagon-like peptide-1 - Wikipedia
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Thus, this extension of the half-life of semaglutide allows for more drug to be absorbed into the stomach cells and reach systemic circulation
Brunetti et al

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In those cases, weight loss may not be appropriate, and a GLP-1 may not be the best first move

Phentermine also prevents neurons from reabsorbing catecholamines after they are released, extending the duration of their appetite-suppressing activity
