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Am J Clin Nutr, 89(1), 106113

The deletion of glucagon-like peptide-1 receptors expressing neurons in the dorsomedial hypothalamic nucleus disrupts the diurnal feeding pattern and induces hyperphagia and obesity

Pharmaceutical GLP-1 agonists offer many health benefits, however their high cost, potential side effects, and weight regain after discontinuation or the requirement for lifetime adherence are major deterrents for many individuals, and highlight the need for more accessible options with improved safety profiles

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What were the most common adverse effects, and which patients were most susceptible