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Surprisingly, most studies have shown that GLP-1RAs not only can reduce the weight of patients with PCOS, but also have a positive effect on the levels of androgens (160, 161)

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Last reviewed: May 14, 2026 Last updated: May 14, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

Glucagon-like peptide-1 (GLP-1) receptor agonists: applications in childhood diabetes and obesity