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14 Obesity can also impact the pharmacokinetics of therapies through changes to volume of distribution and drug clearance, 15 and may negatively alter the efficacy of therapies used to treat IBD

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This activates protein kinase A (PKA), which phosphorylates NHE3 at specific sites (serines 552 and 605)

Cao Y, Hlscher C, Hu M-M, Wang T, Zhao F, Bai Y, et al

There are no symptoms for high cholesterol, but some health conditions that can lead to unhealthy cholesterol levels include:9 Chronic kidney disease Diabetes HIV/AIDS Hypothyroidism Lupus Cholesterol can also be elevated by certain medications for conditions such as:9 Acne Cancer High blood pressure HIV/AIDS Irregular heart rhythm Organ transplants High cholesterol can cause plaques to accumulate on the walls of your arteries, which can lead to chest pain, heart attack, or stroke
