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Contraindications vary: GLP-1 agonists carry boxed warnings for thyroid cancer risk (based on animal studies) and are contraindicated in personal or family history of medullary thyroid carcinoma

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FDA approved pharmaceuticals: miniperspective

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"GLP-1 Clinical Practice Updates: November 2025 Key Developments." December 2025

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The spread reflects fundamental uncertainty about how fast the market will expand beyond early adopters and into the broader population where access, affordability, and long-term adherence remain open questions

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