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This phenomenon may be the result of its unbalanced dual agonistic effect, favoring GIPR over GLP-1R activity [7], because dose escalation of selective GLP-1R agonists induces undesirable gastrointestinal effects

serum amylase and lipase showed a significant rise among GLP-1RAs users (p 0.001)

In contrast to the case reports on altered renal function seen with exenatide, a pooled analysis of 5,594 participants from 19 randomized, controlled clinical trials of exenatide twice-daily (5 g and 10 g) showed that renal impairment-related adverse events, including acute renal failure, were rare (1.6 per 100 person-years for both groups)

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