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Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells

[How It Works]

Development of a ligand-based proximity labeling strategy enables interrogation of the native cell membrane interactome for the GLP-1 receptor in two cell types, revealing new regulators of receptor-mediated signaling and cell responses.

“The initiation of an SGLT2 inhibitor or a GLP-1 receptor agonist compared with a DPP-IV inhibitor was associated with lower CV events and death without

However, oral drug products with a drug release in the ileum are challenging to develop