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Cumulative probability from Phase I to approval is approximately 7.9%

And any difference in side effects

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Patients should be advised to expect glucose to be in the urine and if they are using urine glucose strips that they will have a positive reading most of the time

Routine monitoring typically includes : HbA1c measurements every 3-6 months to assess long-term blood glucose control Renal function tests (eGFR and urine albumin-to-creatinine ratio), as diabetes can affect kidney function Blood pressure monitoring , as hypertension commonly coexists with type 2 diabetes Lipid profile assessment to manage cardiovascular risk Body weight tracking , as Rybelsus often leads to modest weight reduction Patients with pre-existing diabetic retinopathy should be particularly vigilant, as rapid improvements in glucose control with GLP-1 receptor agonists may temporarily worsen retinopathy