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For patients paying cash or seeking more affordable options, exploring different pharmacy sources can lead to significant savings

50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups

They address the underlying mechanism, semaglutide slowing gastric motility, which in turn slows colonic transit time

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Similar effects were demonstrated by investigators, both before and after revascularization procedures [67, 68]