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Among available agents, dulaglutide (Trulicity) was highlighted for its relatively high brain penetrationreported at approximately 62%and its ability in experimental models to influence oxidative stress, amyloid handling, and neuronal energy metabolism [22]

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GLP-1 medications activate receptors in brain reward circuits that overlap with addiction pathways

In this context, GLP-1 microbiome support is best understood as a gut-focused strategy that may complement fiber intake, microbial diversity, and metabolic balance rather than replace medical guidance or prescribed treatment

Discuss All Medications: Inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements