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Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task

Additionally, some individuals may be taking concomitant medications that affect sleep architecture

Emerging evidence suggests benefits in alcohol use disorder, smoking cessation, asthma, psoriasis, inflammatory bowel disease, depression, food cravings, binge-eating behaviour, and potentially even neurodegenerative disease

The result suggests that sympathetic nervous system activation by GLP-1RA is due to direct activation of AP without bloodbrain barrier or indirect activation of NTS via vagal afferent nerves and AP

The dual mechanism does not appear to reduce the gastroparesis risk