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reported that treatment of human islets with sitagliptin resulted in a sevenfold increase in islet active GLP-1 content ( in vitro treatment of human islets with linagliptin (114) and vildagliptin (115) has been shown to stabilize active GLP-1 in islet supernatants and protect non-diabetic human islets from experimentally induced beta-cell damage (114)

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More recently, weve seen even more weight loss obtained with the drug Tirzepatide, he said, adding that its approved for Type 2 diabetes in the U.S

doi: 10.2337/diab.46.4.615

The choice between semaglutide and tirzepatide depends on factors like efficacy preferences, side effect profiles , insurance coverage, and provider recommendation rather than BMI differences