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Heart rate changes by dose group At the 12 mg dose (the highest tested), the average heart rate increase peaked at approximately 6.7 beats per minute at week 24

GLP-1 medications can trigger this disruption through at least five distinct mechanisms, sometimes acting alone, sometimes in combination

The overarching reason for a measured interpretation of our findings is that analyzing data in a pharmacovigilance dataset (eg, FAERS) is not capable of establishing causality, and such databases are not intended to inform deliberation as to whether protective effects exist

Bone density, kidney function, and liver markers remain stable in most users over extended treatment periods

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