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Description
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Pharmacologically mediated, marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with the occurrence of sporadic abnormalities (vertebra, sternebra, ribs) at greater than or equal to 0.075 mg/kg twice weekly (greater than or equal to 2 times human exposure)

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The medication is metabolized by proteolysis and beta-oxidation with excretion of metabolites in urine and feces, and has a half-life of approximately five days

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