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In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]

I do struggle with nausea a lot on this drug

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There is no single best GLP-1 weight loss medication the right choice depends on your health profile, goals, medical history, and insurance coverage

Regarding tolerability, evidence indicates that GLP-1RAs are safe for non-diabetic obese patients