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7 But other cases are more complex, like osteoarthritis
Solfrizzi, A

Freezing breaks the peptide structure, and the damage does not reverse when it thaws

Relative contraindications requiring careful evaluation include history of pancreatitis, severe gastrointestinal disease, diabetic retinopathy, and significant kidney disease
24,25,28 The L-cells apical surface faces the gut lumen, allowing direct contact with nutrients
