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It is not widely appreciated, however, that in healthy individuals, gastric emptying of nutrients is regulated primarily by inhibitory neurohormonal feedback arising from their interaction with the small intestine, rather than intragastric mechanisms, and that both the length and region of small intestine exposed to nutrients modulate this feedback [12, 13]

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Weight loss remains a central therapeutic driver: A reduction in body weight of at least 7 to 10 percent resolves NASH in approximately 65 to 90 percent of patients

Combination treatments working at different receptors promise weight loss with fewer side effects

doi: 10.1016/j.molmet.2024.102074