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Description
NICE guidelines recommend GLP-1 receptor agonists like Trulicity only when specific clinical criteria are met, including inadequate glycaemic control and BMI thresholds

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Some people inherit variants in peptide pathways that make them more susceptible to GI side effects
Decreased appetite is an expected pharmacological effect rather than an adverse event, though the degree of appetite suppression can be more pronounced than some patients anticipate

Eyth, E., Basit, H
