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Description
Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

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For example, the Krispy Kreme stock was downgraded by several investment banks from buy to hold, with the stock price dropping c.14% in the immediate wake of the SELECT trial announcement in August 2023 (from $14.40 to $12.43) due to the uncertain impact that the rise in weight-loss drugs will have on the future sales of the business

VrintsCAndreottiFKoskinasKCRosselloXAdamoMAinslieJet al2024 ESC guidelines for the management of chronic coronary syndromes

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