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Interventions In all the STEP trials, semaglutide and placebo injection devices were identical in appearance to facilitate blinding

What Is Semaglutide and How It Works Semaglutide belongs to a class of medications called GLP-1 receptor agonists

The most commonly reported side effects of Rybelsus include: Gastrointestinal disturbances nausea (very common, affecting more than 1 in 10 patients), vomiting, diarrhoea, abdominal pain, constipation, and dyspepsia (common, affecting up to 1 in 10 patients) Decreased appetite (common) often contributing to weight loss Hypoglycaemia (common) particularly when used in combination with insulin or sulfonylureas

Some withdrawal symptoms may include: Anxiety Depression Irritability Mood swings Fatigue Headaches Muscle aches Insomnia To provide support, we always have a trained healthcare professional on staff to help ease any discomfort you might experience or answer questions

The increases were broadly consistent with those documented for approved GLP-1 receptor agonists in their respective SmPCs