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Nonetheless, they can be considered as a reasonable secondline addon therapy to metformin, specifically in situations where a more substantial reduction in HbA1c levels is necessary

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Perfil de seguridad El perfil de seguridad de Retatrutida documentado en estudios clnicos publicados (Jastreboff 2023, Rosenstock 2023) se concentra en eventos gastrointestinales mediados por agonismo GLP-1 central: Eventos gastrointestinales (frecuencia alta): nusea, vmito, diarrea y estreimiento, dosis-dependientes y mayoritariamente leves a moderados, con incidencia mxima durante las primeras semanas de titulacin

Atta AA, Ibrahim WW, Mohamed AF, Abdelkader NF (2023b) Targeting 7-nAChR by galantamine mitigates reserpine-induced fibromyalgia-like symptoms in rats: involvement of cAMP/PKA, PI3K/AKT, and M1/M2 microglia polarization

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