sglt2 inhibitor glp 1 agonist combination GLP-1 Receptor Agonists and Inhibitors in Type 2 Diabetes: Pleiotropic Cardiometabolic Effects and Add-on Value of a Combined Therapy | Drugs contraindications to glp 1 agonists

doi:10.1007/s00125-023-05906-7 Jastreboff AM, Kaplan LM, Frias JP, Wu Q, Du Y, Gurbuz S, et al

Both are proven prescription medications that not only help regulate blood sugar but can also assist with weight management for eligible patients

Mechanism of action of GLP-1 receptor agonists: Direct receptor binding These medications bind specifically to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent manner (meaning they work when blood glucose is elevated)

RNA interference To silence GLP-1R and PKA gene expression, cells were transfected with siRNAs using lipofectamine RNAi MAX reagent (Invitrogen)

doi: 10.1210/jc.2010-2435