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J Pediatr (2006) 149(1):4752

Dehydration can worsen common side effects like nausea and fatigue

Participants reported greater BMI loss using tirzepatide compared with semaglutide (median 4.75 versus 3.71 kg m 2

However, its reliance on cell division limits its use to proliferating tissues, excluding those with low cell turnover, such as muscle and neurons 3

Medical Conditions That May Exclude Candidacy Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia type two Severe gastrointestinal conditions such as gastroparesis History of pancreatitis Active gallbladder disease Uncontrolled thyroid disease Severe renal impairment Situations That Require Special Caution Active eating disorders Pregnancy or breastfeeding Significant psychiatric concerns Low appetite baseline Medication Conflicts Insulin regimens Sulfonylureas Chronic steroid therapy Geneva evaluates all interactions carefully before prescribing