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A 2003 law bars Medicare's Part D drug benefit from covering any medication used for weight loss

Higher-risk patients include those in the dose-escalation phase, those with nausea, vomiting, bloating, abdominal pain, early satiety, or reflux symptoms, those on higher doses with GI side effects, and those with known gastroparesis or other conditions that slow gastric emptying

Metformin remains a widely used pharmacological option for PCOS, particularly for women with insulin resistance or impaired glucose tolerance

Zepbound: Generally begins at 2.5 mg given once weekly, with the potential to increase by 2.5 mg every 4 weeks until reaching an effective maintenance dose, which can range from 5 mg to 15 mg

[DOI] [PubMed] [Google Scholar] 545.Buteau J., El-Assaad W., Rhodes C.J., Rosenberg L., Joly E., Prentki M