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GIP also induces osteopontin expression in adipocytes (65), an adipokine associated with obesity-related systemic low grade inflammation (66, 67)

Weightless begins with an interesting Forward from a colleague who cracks open the truth about obesity: that it has been misunderstood and mistreated

How GLP-1 Drugs Affect Brain Chemistry and Mood GLP-1 receptors are distributed throughout the central nervous system, particularly in the hypothalamus, ventral tegmental area, and amygdalaregions that regulate appetite, reward processing, and emotional response

About 90% of the body serotonin is found in the gastrointestinal tract, where it regulates gut motility and communicates with the brainstem through the vagus nerve

Weight cycling, a scenario likely in real-world GLP-1 therapy use due to treatment discontinuation and subsequent weight regain, further increases this risk, as repeated cycles of weight loss and regain are associated with cumulative muscle loss and progressive declines strength [25]