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Quick Answer: GLP-1 injections begin suppressing appetite within one to two weeks, with measurable weight loss starting by week four and hemoglobin A1c reductions evident after 12 to 16 weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Fabio G.D., Romanucci G., Zarrelli M., Giordano M., Zarrelli A

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Comorbid conditions such as type 2 diabetes, hypertension, or sleep apnea may require indefinite GLP-1 continuation for cardiovascular and metabolic protection independent of weight loss goals

This study supports the hypothesis that GLP-1 receptor agonists may reduce the symptom burden in fibromyalgia patients, particularly with regard to opioid dependency, fatigue and pain, wrote Nouran Eshak, MB, ChB, rheumatology fellow at Mayo Clinic and the lead investigator of the study