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In clinical trials, GLP-1 medications produce meaningful weight loss typically 15 to 21% of total body weight

*Table: Reported Influences on Libido with GLP-1/GIP Agonists* A 2022 study in Diabetes, Obesity and Metabolism on tirzepatide noted that quality of life measures related to physical function and self-esteem improved significantly, which often correlates with better sexual health

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Comparative Efficacy and Safety of Different Orforglipron Doses in Patients With Type 2 Diabetes Mellitus and Obesity: A Systematic Review and Network Meta-Analysis