contraindications for glp-1 agonists include Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Receptor Agonists: A Multidisciplinary Expert Consensus Contraindications to Antihyperglycemic Medications in
Description
Average weight loss in studies is helpful for understanding trends, but individuals vary
N Engl J Med (2015) 373:224757
Patients should be counselled to expect these potential side-effects

13 While native GLP-1 has been targeted as a therapeutic agent due to its favorable effects on glycemia, its clinical utility is limited due to its extremely short half-life
The clinical trials excluded participants on certain medications, so comprehensive interaction data is limited