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Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China

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Note that these outcomes were achieved in combination with diet and exercise, underlining the value of a holistic approach to weight loss and blood sugar management

These drugs are, indeed, effective for weight loss

Pathogenic homozygous or compound heterozygous variants in genes encoding components of this pathwayincluding MC4R, POMC, LEP (leptin), and LEPRcan result in early-onset severe obesity [72]