glp 1 agonist therapy GLP-1 Medications for Weight Loss: Semaglutide vs Tirzepatide vs Retat – Revolution Health & Wellness Metabolic Flux Adaptations During GLP-1
Description
Chronic co-administration of selective mono-agonists to obese non-human primates resulted in significantly more body weight loss when compared to the individual treatments, thus demonstrating the translation of these acute effects observed in humans and the chronic effects observed in primates [673]

This is very different from natural GLP-1 hormones, which rise and fall in complex patterns finely tuned to your food intake and other behaviors

For "Cardiovascular risk reduction," Semaglutide may be more appropriate

Glucagon-like peptide 1-based therapies and risk of pancreatitis: a self-controlled case series analysis
The role of FGF21 and its analogs on liver associated diseases
