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Furthermore, evidence has shown that once-weekly versus once-daily administration of subcutaneous GLP-1RAs led to improvements in treatment persistence and adherence [10]

The clinical significance of this interaction is highest with antineoplastic doses of methotrexate, but if a patient on antirheumatic doses of methotrexate can receive an alternative class to PPIs, it is the safest option to avoid any risk of methotrexate toxicity and delayed methotrexate elimination

One well-known side effect is Ozempic face, where individuals experience sagging skin and a gaunt appearance