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Despite these limitations, a tentative pattern emerges: acute GLP-1 RA administration might reduce brain reactivity to high-calorie food cues within key reward and salience regions, including the striatum, anterior cingulate cortex (ACC), insula, and orbitofrontal cortex (OFC)

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doi: 10.3390/ijms22031500

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The subjective experience of appetite reduction typically becomes noticeable around weeks two to four at starting doses

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