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Conversely, pathways related to PPAR signalling, the protein-lipid complex, and calmodulin binding were downregulated ( Figure S8 )

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While skeletal muscle is the biggest component of LBM, it is not the only one, and changes in LBM do not translate directly to changes in muscle

Emerging preclinical and clinical evidence suggests these medications may modulate reward-seeking behaviour and reduce the reinforcing effects of alcohol, though this remains an area of active investigation rather than established clinical practice