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, Newsholme, P

Clinical studies have revealed that semaglutide GLP-1 can result in substantial weight loss, with some participants experiencing an average reduction of 15% or more of their initial body weight

Rotating between these sites prevents localized reactions like lipodystrophy, where the fat tissue at a repeatedly used site changes texture
In patients with diabetes and a history of peripheral vascular events, GLP-1 therapies were associated with reduced risk of amputation, major adverse cardiovascular events, cardiovascular death, all-cause mortality, and progression to dialysis compared with other glucose-lowering medications (Hsiao et al., 2026)

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