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Semaglutide works through appetite and glucose regulation pathways that don't require a functioning thyroid
They approach it through the lens of comorbidity

However, glycemic control improved markedly, with HbA1C reductions of 2.0-2.5% from baselines typically around 8.0-8.5%

The pharmacodynamic and pharmacokinetic differences between nonselective and selective -blockers have clinical implications for their use in various conditions, including heart failure, hypertension and arrhythmias
