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Food and Drug Administration approved the semaglutide injection (2.4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), for use in addition to a reduced calorie diet and increased physical activity

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XIGDUO XR is contraindicated in patients with an eGFR below 30 mL/min/1.73 m2 and endstage renal disease due to the metformin HCl component [see Contraindications (4), Warnings and Precautions (5.1, 5.2), and Use in Specific Populations (8.6)]