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Nature 396 , 743746 (1998)

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GLP-1 RAs offer improved glycaemia, weight loss and cardiovascular benefits in those for whom they are recommended by the guidelines, so it is important that we facilitate their initiation and continuation in as many appropriate people as possible

Obesity and Metabolic Syndrome Research in diet-induced obesity models showed that MOTS-c treatment resulted in: Significant reduction in body weight gain despite continued high-fat diet consumption Decreased adipose tissue accumulation and reduced hepatic steatosis Improved lipid profiles with reduced circulating triglycerides Enhanced metabolic flexibility between carbohydrate and fat oxidation Plasma metabolomics studies in obese mice identified MOTS-c-mediated decreases in metabolic markers associated with obesity and type 2 diabetes

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